High hepatocytes turnover results in the accumulation of genetic errors and mutations resulting in the formation of dysplastic hepatocytes and hepatic nodules resulting in HCC occurrence. Excessive metabolic and oxidative stress in cirrhotic liver results in excessive hepatocytes regeneration. Cirrhosis is the most common predisposing factor for HCC development. This process results in chronic liver disease which leads to the generation of fibrosis followed by cirrhosis. Chronic inflammation results in necrotic effect in hepatocytes which triggers a regeneration process. Graphical AbstractÄevelopment of HCC is often associated with the induction of inflammation related hepatic injury. In this review, the effect of utilizing lipidic nanoparticles is being discussed as well as the different tumor uptake enhancement techniques used. Multiple approaches are used to enhance the tumor uptake as well tumor specificity such as intratumoral injection, passive targeting, active targeting, and stimuli responsive nanoparticles. Multiple forms of lipid based nanoparticles exist including liposomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion, nanoemulsion, phytosomes, lipid coated nanoparticles, and nanoassemblies. In order to improve the treatment outcomes, utilizing nanoparticles-specifically lipid based nanoparticles-are considered to be one of the most promising approaches being set in motion. Focusing on drug treatment, regular agents in conventional forms fail to achieve the intended clinical outcomes. Multiple conventional approaches are being used in treating hepatocellular carcinoma. Among the different types of liver cancer, hepatocellular carcinoma is considered to be the most common type. Liver cancer is considered one of the deadliest diseases with one of the highest disease burdens worldwide.